Nitric Oxide is a Amazing Molecule Which May Prolong Life...Anti-Aging
02, 2013 dianna
Nitric Oxide boosts blood flow, oversees the immune system, fights infections, transmits nerve signals and prolongs life
Nitric Oxide (NO), is a versatile gas that boosts blood flow, regulates immune function, fights infections and transmits nerve signals. It also performs another biological function, that of prolonging the life of an organism and fortifying it against environmental stress, according to a new study conducted by Evgeny Nudler PhD.
The research found that a roundworm called Caenorhabditis elegans, an animal broadly used in laboratory studies on aging, lives substantially longer when fed bacteria capable of creating Nitric Oxide.
It was determined that the microbiome, consisting of trillions of microbial cells inhabiting our bodies, may play a essential role in our health.
Our own Nitric Oxide levels decrease as we age, this may contribute to normal aging, according to Dr. Evgeny Nudler, at New York University Langone Medical Center, as part of the Julie Wilson Anderson Professor Biochemistry.
We now know that bacteria in worms can use Nitric Oxide to benefit their host as well as themselves. The comparable thing could be true in a human gut.
It may well be the case that our commensal bacteria control some of our genes to protect those cells against aging and stress. Commensal bacteria afford healthy benefits to the organisms they colonize.
Although human beings and other organisms have the enzyme needed to produce Nitric Oxide, C elegans do not. Alternatively, the worm can seize control of the compound from the soil-dwelling Bacillus subtilis bacterium which is a favored food and a common colonist within its gut.
This ability Dr. Nudler said, in some measure explains why worms fed B subtilis live approximately 50 per cent longer than those fed Escherichia coli, which does not generate the compound.
When the investigators fed the worms Nitric Oxide-producing B subtilis bacteria, compared to worms fed mutant B subtilis with a deleted Nitric Oxide production gene, the average C elegans lifespan increased by nearly 15 per cent, to almost two weeks.
The study group used fluorescent sensors to demonstrate that C elegans do not make its own Nitric Oxide. When the worms were supplied with normal B subtilis bacteria, the fluorescent signal showed up in their guts. Tests showed that B. subtilis-derived Nitric Oxide penetrated the worms' tissues, where it activated a set of 65 genes. Resulting in increased lifespan, better immune response, and a high stress level resistance.
Keywords: Nitric Oxide, Nitric Oxide (NO), Nitric Oxide benefits, aging, antiaging, ageing, antiageing, immune system, infections, nerve signals, Nitric Oxide stress, prolong life
Resources:
NYU Langone Medical Center
http://newsandviews.med.nyu.edu/curious-career-dr-evgeny-nudler
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"The discovery of Nitric Oxide is one of the most important in the history of cardiovascular medicine" ~ President of the American Heart Association
"Nitric Oxide is the body's way of protecting against cardiovascular disease" ~ UCLA Department of Molecular and Medical Pharmacology
"Any risk factor for cardiovascular disease is associated with loss of Nitric Oxide." ~ Mayo Clinic Research
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